IC/BPS is a chronic disease of uncertain etiology that is characterized by urgency, frequency, and suprapubic pain related to bladder filling. A recent review found that patients with IC/BPS often have other unexplained conditions and symptoms and is known to commonly coexist with other regional and systemic pain conditions, such as irritable bowel syndrome (IBS), fibromyalgia (FM), chronic fatigue syndrome (CFS), and migraine headaches. Some studies considered that based on these associations, it has been suggested that IC/BPS may progress from an organ-specific phenotype to a regional phenotype and then to a systemic phenotype. However, there are no data about symptoms severity between with and without comorbid disease. The purpose of this study was to examine the prevalence and symptoms of non-bladder conditions in a physian-diagnosed of women with IC/BPS.